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The treatment and regenerative medicine approaches discussed are based on early-stage research and have not yet been approved by the FDA

thaliana wild-type plants, as well as in plants lacking the two cytosolic NADPH-dependent thioredoxin reductases ntr a/b or cytosolic glutathione reductase gr1 ( Figure 6 and Figure S14 )

Mitochondria are major sources of free radicals, and in addition to being commonly used to treat disoriented circadian clocks due to jet lag and other disturbances (i.e., sleep inefficiency) 18 , melatonin has been widely used as an antioxidative therapy 19 and its use dates back to 1993 (refs

In contrast, K d-la and K ce are produced by nonenzymatic reactions as a result of chemically reactive glycolytic by-products escaping from the cellular detoxification system